Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.701 0.083 0.167
biological_process el 70 0.078 0.971 0.655 0.284
biological_process ka 70 0.0 0.682 0.079 0.167
biological_process rf 70 0.0 0.701 0.083 0.167
cellular_component ct 71 0.0 0.917 0.116 0.192
cellular_component el 71 0.007 0.967 0.388 0.276
cellular_component ka 71 0.0 0.966 0.118 0.196
cellular_component rf 71 0.0 0.917 0.116 0.192
disease ct 25 0.001 0.945 0.154 0.273
disease el 25 0.014 0.86 0.589 0.236
disease ka 25 0.0 0.944 0.165 0.293
disease rf 25 0.001 0.935 0.154 0.271
genetic_interaction ct 63 0.0 1.0 0.423 0.327
genetic_interaction el 63 0.0 1.0 0.451 0.333
genetic_interaction ka 63 0.0 1.0 0.937 0.244
genetic_interaction rf 63 0.0 1.0 0.444 0.337
molecular_function ct 71 0.0 0.951 0.142 0.258
molecular_function el 71 0.048 0.991 0.457 0.235
molecular_function ka 71 0.0 0.943 0.144 0.259
molecular_function rf 71 0.0 0.951 0.14 0.257
pathway ct 30 0.001 0.996 0.069 0.18
pathway el 30 0.001 0.185 0.027 0.047
pathway ka 30 0.001 1.0 0.307 0.454
pathway rf 30 0.001 0.157 0.03 0.044
phenotype ct 26 0.0 0.937 0.196 0.275
phenotype el 26 0.016 0.976 0.571 0.276
phenotype ka 26 0.0 1.0 0.222 0.312
phenotype rf 26 0.0 0.933 0.196 0.275
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.001 1.0 0.347 0.471
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.853 0.115 0.223
integration_mean_by_presence el 73 0.0 0.893 0.175 0.229
integration_mean_by_presence ka 73 0.0 0.733 0.05 0.137
integration_mean_by_presence rf 73 0.0 0.352 0.026 0.063
mean ct 73 0.0 0.828 0.093 0.212
mean el 73 0.0 0.821 0.102 0.171
mean ka 73 0.0 0.469 0.034 0.088
mean rf 73 0.0 0.349 0.033 0.075

CDF plots of non integrated kernels

CDF plots of integrated kernels